Multiplexed Cells Micropatterning Using Capillary Assembly

نویسندگان

  • François-Damien Delapierre
  • Guillaume Mottet
  • Velan Taniga
  • Laurent Malaquin
چکیده

This paper reports a novel technology to localize the immobilization of different types of particles or cells on a surface with a sub-micrometric precision in order to study their interactions. The process uses capillary assembly on arrays of crescent-shaped structures with different orientations. Successive assemblies in different substrate orientations with different types of particles allow for the creation of imbricated arrays with sub-micrometer particle positioning accuracy. Using this process, antibody coated microparticles were assembled on substrates and used as capture patterns for the creation of complex cell networks.

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تاریخ انتشار 2012